Abstract
Methods: A novel series of isoxazole (S21-S30) derivatives were designed, synthesized and screened for their anticancer activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer cell lines. The synthesized derivative has the ability to inhibit the growth of the human breast cancer cell line at low concentrations. In vivo anticancer activity was performed on virgin female sprague dawley rats.
Results: The result shows that compound S23 has more selectivity and marked estrogen modulator activity than the standard tamoxifen.
Keywords: Chalcone, isoxazole, breast cancer, estrogen receptor, S21-S30, tamoxifen.
Anti-Cancer Agents in Medicinal Chemistry
Title:Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent
Volume: 18 Issue: 7
Author(s): Santosh N. Mokale*, Nikhil S. Sakle, Swati A. Bhavale, Deepak K. Lokwani and Vishakha R. Shelke
Affiliation:
- Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad-431001, Maharashtra,India
Keywords: Chalcone, isoxazole, breast cancer, estrogen receptor, S21-S30, tamoxifen.
Abstract: Methods: A novel series of isoxazole (S21-S30) derivatives were designed, synthesized and screened for their anticancer activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer cell lines. The synthesized derivative has the ability to inhibit the growth of the human breast cancer cell line at low concentrations. In vivo anticancer activity was performed on virgin female sprague dawley rats.
Results: The result shows that compound S23 has more selectivity and marked estrogen modulator activity than the standard tamoxifen.
Export Options
About this article
Cite this article as:
Mokale N. Santosh *, Sakle S. Nikhil , Bhavale A. Swati , Lokwani K. Deepak and Shelke R. Vishakha , Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent, Anti-Cancer Agents in Medicinal Chemistry 2018; 18 (7) . https://dx.doi.org/10.2174/1871520618666171129153655
DOI https://dx.doi.org/10.2174/1871520618666171129153655 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Molecular Pathways of Interferon-Stimulated Gene 15: Implications in Cancer
Current Protein & Peptide Science SUBJECT INDEX TO VOLUME 1
Current Genomics Counselling and Cognitive Behaviour Interventions Delivered to Reduce Psychological Morbidity and Improve Quality of Life in Gynaecological Cancer Patients: Recent Achievements
Current Women`s Health Reviews Phytoconstituents of <i>Lantana camara</i> L.: Rekindling Hope in the Cancer Treatment
Current Bioactive Compounds ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis
Current Pharmaceutical Design Vitamin D Analogs as Anti-Carcinogenic Agents
Anti-Cancer Agents in Medicinal Chemistry Probiotics as an Alternative Strategy for Prevention and Treatment of Human Diseases: A Review
Inflammation & Allergy - Drug Targets (Discontinued) Stroke in Women - Oral Contraception, Pregnancy, and Hormone Replacement Therapy
Current Vascular Pharmacology Polymeric Drug Delivery Approaches for Colon Targeting: A Review
Drug Delivery Letters Effect of Paclitaxel-Loaded PLGA Nanoparticles on MDA-MB Type Cell Lines: Apoptosis and Cytotoxicity Studies
Current Pharmaceutical Design Expression of NRP-1 and NRP-2 in Endometrial Cancer
Current Pharmaceutical Biotechnology Patenting Penicillium Strains
Recent Patents on Biotechnology Biomarkers and Osteosarcoma and IGF
Recent Patents on Biomarkers Liver Transporters in Hepatic Drug Disposition: An Update
Current Drug Metabolism A Classification Method for Microarrays Based on Diversity
Current Bioinformatics Spectrum of Multimodality Findings in Post-surgical Breast Cancer Imaging
Current Medical Imaging UPA and PAI-1 Analysis from Fixed Tissues – New Perspectives for a Known Set of Predictive Markers
Current Medicinal Chemistry Dietary Polyphenols for Treatment of Alzheimer’s Disease– Future Research and Development
Current Pharmaceutical Biotechnology Targeting Tumor Microenvironment with Silibinin: Promise and Potential for a Translational Cancer Chemopreventive Strategy
Current Cancer Drug Targets Understanding the Role of Poloxamer 407 based Thermoreversible In Situ Gelling Hydrogel for Delivery of PEGylated Melphalan Conjugate
Current Drug Delivery