Title:Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent
VOLUME: 18 ISSUE: 7
Author(s):Santosh N. Mokale*, Nikhil S. Sakle, Swati A. Bhavale, Deepak K. Lokwani and Vishakha R. Shelke
Affiliation:Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad-431001, Maharashtra, Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad-431001, Maharashtra, Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad-431001, Maharashtra, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, Dist-Dhule, Maharashtra, Dr. Rafiq Zakaria Campus, Y. B. Chavan College of Pharmacy, Aurangabad-431001, Maharashtra
Keywords:Chalcone, isoxazole, breast cancer, estrogen receptor, S21-S30, tamoxifen.
Abstract:Methods: A novel series of isoxazole (S21-S30) derivatives were designed, synthesized and screened
for their anticancer activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer
cell lines. The synthesized derivative has the ability to inhibit the growth of the human breast cancer cell line at
low concentrations. In vivo anticancer activity was performed on virgin female sprague dawley rats.
Results: The result shows that compound S23 has more selectivity and marked estrogen modulator activity than
the standard tamoxifen.
