Abstract
Alzheimer's disease is a neurodegenerative condition affecting millions of people worldwide. Alzheimer's symptoms include memory loss and cognitive decline. Pathologically, the hallmarks of Alzheimer´s are the presence of Amyloid beta-plaques, neurofibrillary tangles, and neuronal loss. Unfortunately, no cure is presently available and current treatments are only symptomatic. Transforming growth factor beta type I (TGF-β1) is a trophic factor involved in neuronal development and synaptic plasticity. Impairment of TGF-β1 signaling is associated with exacerbated Aβ deposition and neurofibrillary tangle formation, which increases neurodegeneration. Aging and chronic inflammation reduce the canonical TGF-β1/Smad signaling, facilitating cytotoxic activation of microglia and microgliamediated neurodegeneration This review gathers together evidence for a neuroprotective role of TGF-β in Alzheimer’s disease. Restoring TGF-β1 signaling impairment may be a new pharmacological strategy Alzheimer’s treatment.
Keywords: Transforming growth factor-β1, Alzheimer´s disease, amyloid-beta, oligomers, Smad signaling, neuroprotection, neuroinflammation, microglia.
Current Protein & Peptide Science
Title:Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer´s Disease
Volume: 19 Issue: 12
Author(s): Lisbell D. Estrada*, Luciana Oliveira-Cruz and Daniel Cabrera
Affiliation:
- Centro Integrativo de Biologia y Quimica Aplicada (CIBQA), Universidad Bernardo O Higgins, Santiago,Chile
Keywords: Transforming growth factor-β1, Alzheimer´s disease, amyloid-beta, oligomers, Smad signaling, neuroprotection, neuroinflammation, microglia.
Abstract: Alzheimer's disease is a neurodegenerative condition affecting millions of people worldwide. Alzheimer's symptoms include memory loss and cognitive decline. Pathologically, the hallmarks of Alzheimer´s are the presence of Amyloid beta-plaques, neurofibrillary tangles, and neuronal loss. Unfortunately, no cure is presently available and current treatments are only symptomatic. Transforming growth factor beta type I (TGF-β1) is a trophic factor involved in neuronal development and synaptic plasticity. Impairment of TGF-β1 signaling is associated with exacerbated Aβ deposition and neurofibrillary tangle formation, which increases neurodegeneration. Aging and chronic inflammation reduce the canonical TGF-β1/Smad signaling, facilitating cytotoxic activation of microglia and microgliamediated neurodegeneration This review gathers together evidence for a neuroprotective role of TGF-β in Alzheimer’s disease. Restoring TGF-β1 signaling impairment may be a new pharmacological strategy Alzheimer’s treatment.
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Cite this article as:
Estrada D. Lisbell *, Oliveira-Cruz Luciana and Cabrera Daniel , Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer´s Disease, Current Protein & Peptide Science 2018; 19 (12) . https://dx.doi.org/10.2174/1389203719666171129094937
DOI https://dx.doi.org/10.2174/1389203719666171129094937 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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