Title:Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects
VOLUME: 15 ISSUE: 6
Author(s):Dominik Szwajgier*, Ewa Baranowska-Wojcik and Kamila Borowiec
Affiliation:Department of Biotechnology, University of Life Sciences in Lublin, Human Nutrition and the Science of Food Commodities, Skromna Street 8, Lublin 20-950, Department of Biotechnology, University of Life Sciences in Lublin, Human Nutrition and the Science of Food Commodities, Skromna Street 8, Lublin 20-950, Department of Biotechnology, University of Life Sciences in Lublin, Human Nutrition and the Science of Food Commodities, Skromna Street 8, Lublin 20-950
Keywords:Alzheimer's disease, amyloid β-peptide, cinnamic acid, benzoic acid, acetylcholinesterase, butyrylcholinesterase,
cognition.
Abstract:Numerous authors have provided evidence regarding the beneficial effects of phenolic acids
and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors
of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the
structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of
amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning
the prevention and treatment of the cognitive enhancement.
