This review brings forth the potential of thiazole derivatives for their anticancer activities.
The emphasis is placed on the structural diversity of thiazole derivatives, responsible for their specific
anticancer activity. Multiple classes of thiazole derivatives such as Schiff base, mono-, di-, tri-, and
heterocyclic substituents that possess anticancer activity have been exemplified. Molecular modelling
of compounds that predicts enhanced anticancer activity of the modified structures has also been elaborated
in the review. Significant advancements in synthetic chemistry related to cytotoxicity can now
better position the drug discovery team to undertake thiazoles as valuable leads. The beneficial thiazole
derivatives possessing anticancer activity will reignite the interest of medicinal chemists in thiazole
and their derivatives.
Keywords: Anticancer, biological activity, HIV, thiazole, thiazole derivatives, structure-activity relationship.
Rights & PermissionsPrintExport