Anticancer Potential of Thiazole Derivatives: A Retrospective Review

Author(s): Shweta Jain, Satyanarayan Pattnaik, Kamla Pathak, Sushant Kumar, Devender Pathak, Surendra Jain, Ankur Vaidya*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 8 , 2018

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


This review brings forth the potential of thiazole derivatives for their anticancer activities. The emphasis is placed on the structural diversity of thiazole derivatives, responsible for their specific anticancer activity. Multiple classes of thiazole derivatives such as Schiff base, mono-, di-, tri-, and heterocyclic substituents that possess anticancer activity have been exemplified. Molecular modelling of compounds that predicts enhanced anticancer activity of the modified structures has also been elaborated in the review. Significant advancements in synthetic chemistry related to cytotoxicity can now better position the drug discovery team to undertake thiazoles as valuable leads. The beneficial thiazole derivatives possessing anticancer activity will reignite the interest of medicinal chemists in thiazole and their derivatives.

Keywords: Anticancer, biological activity, HIV, thiazole, thiazole derivatives, structure-activity relationship.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2018
Published on: 23 November, 2017
Page: [640 - 655]
Pages: 16
DOI: 10.2174/1389557517666171123211321
Price: $65

Article Metrics

PDF: 44
PRC: 1