Background: Nanotechnology has demonstrated great potential for the cure of bone infections
through the development of antibacterial nanomaterials. The bone diseases include many skeletal-
related illnesses such as arthritis, bone cancer, osteosarcoma and osteoarthritis, which are the
major causes of mortality in human beings. Moreover, there are no effective treatment strategies
available for such bone diseases. However, these limitations create pressing need to search safe and
efficient novel drugs for clinical treatments. In this context, nanotechnology- based targeted drug
delivery is widely proposed as an effective treatment strategy.
Objective: Recently, various nanomaterials have been extensively used in the management of bone
diseases. Therefore, we aimed to write a comprehensive review on the role of nanotechnology in
Methods: We searched Google and PubMed portals extensively concerning literature of the following
subjects so as to get latest updated information related to current developments in the field of
nanotechnology in the context of bone diseases.
Results: In the present review, we have discussed the role of the various nanomaterials, which can be
promisingly used in the diagnosis and treatment of dentistry and bone cancer. Further, biomedical
applications of nanomaterials like imaging, diagnostic, drug delivery and their use as regenerative
bone substitutes have also been discussed.
Conclusions: Considering the recent advances in the field, it can be concluded that the development
of nano-based approaches can be possible, which will play important role in the diagnosis and treatment
of bone diseases, bone regeneration, and tissue reconstruction.