Background: Lipid nanoparticles have attracted increased degree of scientific and commercial attention
in the last decade. The lipidic nanoparticles have emerged as a potential alternative to other nano-scale systems
due to their various advantages over them and also due to overcoming the shortcomings of the already available
colloidal systems like liposomes, niosomes and polymeric nanoparticles.
Description: These have been investigated for delivery of macromolecules, genes, siRNA and other therapeutic
agents for oral, topical, parenteral administration and target site specific delivery for various diseases like cancer,
ocular diseases and brain disorders. The lipid nanoparticles have evolved from SLNs, then NLCs and lipid drug
conjugates overcoming any issues related to production and formulation and adding advantages, if any. The current
review article focuses on the lipid nanoparticles, their formulation approaches and current advancements in
the field through recent clinical trials and patents. This manuscript embodies various patents, preclinical and
clinical aspects related to the lipidic nanocarriers.
Conclusion: Over the years the lipidic nanoparticulate systems have evolved as significant carriers for improved
therapeutics and in diagnostic field. The large number of patents and preclinical trials in the recent years suggests
that these systems will find immense potential in near future.