Title:Natural Compounds in the Chemoprevention of Malignant Melanoma
VOLUME: 18 ISSUE: 5
Author(s):Corina Danciu*, Codruta Soica, Diana Antal, Ersilia Alexa, Ioana Z. Pavel, Roxana Ghiulai, Florina Ardelean, Roxana M. Babuta, Alexandra Popescu and Cristina A. Dehelean
Affiliation:Department of Pharmacognosy, Faculty of Pharmacy, , Department of Pharmaceutical Chemistry, , Department of Pharmaceutical Botany, , Department of Food Control, Banat’s University of Agricultural Sciences and Veterinary Medicine , Department of Pharmacognosy, Faculty of Pharmacy, , Department of Pharmaceutical Chemistry, , Department of Pharmaceutical Botany, , Department of Pharmacognosy, Faculty of Pharmacy, , Department of Physical Chemistry, , Department of Toxicology
Keywords:Malignant melanoma, natural compounds, chemoprevention, skin cancer, melanocytes, biochemical pathways.
Abstract:Malignant melanoma is a very aggressive form of skin cancer, with increasing rates every year, with
an etiology that derives from the transformation and uncontrolled growth of melanocytes. There are several
treatment options which can be used as unique treatment or combined, depending upon the stage of melanoma
including surgical excision, chemotherapy, immunotherapy, targeted therapy. Plant Kingdom displays an unequalled
potential for the synthesis of highly diversified chemical structures. Although natural compounds are
synthesized in order to help the plant to interact with the environment, a large number of phytochemicals act as
drugs within the human or animal body by activating various biochemical pathways. The study aims to review
another approach in the management of this highly aggressive form of skin cancer, namely the effect of natural
compounds in the chemoprevention of malignant melanoma.
