Natural Compounds in the Chemoprevention of Malignant Melanoma

Author(s): Corina Danciu*, Codruta Soica, Diana Antal, Ersilia Alexa, Ioana Z. Pavel, Roxana Ghiulai, Florina Ardelean, Roxana M. Babuta, Alexandra Popescu, Cristina A. Dehelean

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 18 , Issue 5 , 2018

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Graphical Abstract:


Malignant melanoma is a very aggressive form of skin cancer, with increasing rates every year, with an etiology that derives from the transformation and uncontrolled growth of melanocytes. There are several treatment options which can be used as unique treatment or combined, depending upon the stage of melanoma including surgical excision, chemotherapy, immunotherapy, targeted therapy. Plant Kingdom displays an unequalled potential for the synthesis of highly diversified chemical structures. Although natural compounds are synthesized in order to help the plant to interact with the environment, a large number of phytochemicals act as drugs within the human or animal body by activating various biochemical pathways. The study aims to review another approach in the management of this highly aggressive form of skin cancer, namely the effect of natural compounds in the chemoprevention of malignant melanoma.

Keywords: Malignant melanoma, natural compounds, chemoprevention, skin cancer, melanocytes, biochemical pathways.

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Article Details

Year: 2018
Page: [631 - 644]
Pages: 14
DOI: 10.2174/1871520617666171121142522
Price: $65

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PDF: 59
PRC: 1