Inodilators are a heterogeneous group of drugs with vasodilatory and inotropic effects. The
cardioprotective effect of levosimendan is multifactorial, but now research on levosimendan is focused
on the organ-protective properties of this drug in different settings, the regimen that seems to provide
the greatest cardiologic and systemic benefits is early administration of levosimendan. We try to answer
four questions in this review, which type of patients need this drug? what is the best time to start with it?
and the best way that we could give it and finally the reasons for use it.
Keywords: Levosimendan, preconditioning, postconditioning, mechanisms, cardiac surgery, calcium sensitizers.
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