Background: Due to the need and adverse effects associated with the available
anti-inflammatory agents, an attempt was made to develop the new anti-inflammatory
agents with better activity and lesser adverse effects.
Objective: Synthetic approaches based on chemical modification of NSAIDs have been undertaken
with the aim of improving NSAIDs safety profile.
Method: In the present study, a series of thiazole derivatives (3a-3x) was synthesized and
tested for its anti-inflammatory with analgesic and nitric oxide releasing properties. In this
work, synthesis of molecules containing substituted diaryl ring on 5-membered thiazole ring
with nitric oxide releasing moiety is described.
Results: Out of the twenty four synthesized compounds, five compounds showed considerable
anti-inflammatory and analgesic activity in comparison with the standard. Most of the
synthesized compounds showed considerable nitric oxide-releasing property. The molecular
docking study was used to rationalize binding interaction at the active site and the result
showed good binding interaction.
Conclusion: From the results of pharmacological studies, we conclude that the synthesized
compounds have not only retained, but showed enhanced anti-inflammatory and analgesic