Title:Insight into the Role of Long Non-coding RNAs During Osteogenesis in Mesenchymal Stem Cells
VOLUME: 13 ISSUE: 1
Author(s):Sibei Huo, Yachuan Zhou, Xinyu He, Mian Wan, Wei Du, Xin Xu, Ling Ye, Xuedong Zhou and Liwei Zheng*
Affiliation:State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 61004, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 61004, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 61004, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 61004, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 61004, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 61004, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 61004, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 61004, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 61004
Keywords:Long non-coding RNA, osteogenesis, odontogenesis, mesenchymal stem cells, bone-related diseases, oral diseases.
Abstract:Background: Long non-coding RNAs (LncRNAs) are non-protein coding transcripts longer
than 200 nucleotides in length. Instead of being “transcriptional noise”, lncRNAs are emerging as a
key modulator in various biological processes and disease development. Mesenchymal stem cells can
be isolated from various adult tissues, such as bone marrow and dental tissues. The differentiation
processes into multiple lineages, such as osteogenic differentiation, are precisely orchestrated by molecular
signals in both genetic and epigenetic ways. Recently, several lines of evidence suggested the
role of lncRNAs participating in cell differentiation through the regulation of gene transcriptions. And
the involvement of lncRNAs may be associated with initiation and progression of mesenchymal stem
cell-related diseases.
Objective: We aimed at addressing the role of lncRNAs in the regulation of osteogenesis of mesenchymal
stem cells derived from bone marrow and dental tissues, and discussing the potential utility of
lncRNAs as biomarkers and therapeutic targets for mesenchymal stem cell-related diseases.
Results: Numerous lncRNAs were differentially expressed during osteogenesis or odontogenesis of
mesenchymal stem cells, and some of them were confirmed to be able to regulate the differentiation
processes through the modifications of chromatin, transcriptional and post-transcriptional processes.
LncRNAs were also associated with some diseases related with pathologic differentiation of mesenchymal
stem cells.
Conclusion: LncRNAs involve in the osteogenic differentiation of bone marrow and dental tissuederived
mesenchymal stem cells, and they could become promising therapeutic targets and prognosis
parameters. However, the mechanisms of the role of lncRNAs are still enigmatic and require further
investigation.
