Title:Development and Tailoring of Hybrid Lipid Nanocarriers
VOLUME: 23 ISSUE: 43
Author(s):German A. Islan, Maximiliano L. Cacicedo, Boris Rodenak-Kladniew, Nelson Duran and Guillermo R. Castro*
Affiliation:Laboratorio de Nanobiomateriales, CINDEFI (UNLP-CONICET CCT La Plata) Departamento de Quimica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Laboratorio de Nanobiomateriales, CINDEFI (UNLP-CONICET CCT La Plata) Departamento de Quimica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Instituto de Investigaciones Bioquimicas de La Plata (INIBIOLP), CONICET-UNLP, CCT-La Plata, Facultad de Ciencias Medicas, La Plata, Brazilian Nanotechnology National Laboratory (LNNano-CNPEM), Campinas, SP, Laboratorio de Nanobiomateriales, CINDEFI (UNLP-CONICET CCT La Plata) Departamento de Quimica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata
Keywords:Lipid drug delivery systems, lipid particulate systems, solid lipid nanoparticles, nanostructured lipid carriers, hybrid lipid
nanoparticles, hydrophobic drugs, lipid toxicity
Abstract:Background: Lipid nanoparticles are considered one of the most promising systems for controlled
release of therapeutic molecules highly hydrophobic and with low biodisponibility. Solid lipid nanoparticles and
nanostructured lipids carriers are widely seen as the workhorses of drug delivery systems because of low toxicity,
enhanced encapsulation capacity, controlled drug kinetic release, easy tailoring and targeting and practicable scale
up.
Conclusions: A new generation of hybrid lipid nanoparticles has emerged by combining the lipidic properties
with polymers, proteins and metallic structures. The main features of hybrid lipid nanoparticles including popular
methods for synthesis and characterization, biological and toxicological properties, administration routes, drug
encapsulation strategies, tailoring and targeting, and potential systems for use in biomedicine are described in the
present review.
