ISATIN: New Hope Against Convulsion

Author(s): Rameshwar S. Cheke, Sandip D. Firke*, Ravindra R. Patil, Sanjay B. Bari

Journal Name: Central Nervous System Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Central Nervous System Agents

Volume 18 , Issue 2 , 2018

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Graphical Abstract:


Background: Epilepsy is one in every of the foremost important chronic neurological disorders with high incidence worldwide. Several epileptic patients don’t seem to be fully treated with currently available marketed medicines likewise so many drugs have shown unfavorable side effect and drug interaction. Therefore, there are continuing interests to seek out new anticonvulsant drugs.

Methods: Literature search was carried out to indentify isatin containing derivatives as anticonvulsant drugs.

Results: Common synthetic schemes were studied to design and develop isatin derives anticonvulsant agents. Various structural features essential for the design of isatin compounds were reported. Anticonvulsant activity is evaluated by different tests were identified and their results can be considered for the design of novel isatin derivatives as anticonvulsants.

Conclusion: In outline, isatin has been proved to be an excellent hybrid building the molecule with interesting biological activities. Among the prospect of derivatizing the N1, C2 and C3 positions, along with substitution on the aromatic ring, the synthetic modification for isatin is almost endless. Despite the fact that isatin derivatives are well-studied compounds, new derivatives are continually being discovered on the basis of known AEDs, isatin has been fused with other bioactive drug fragments and subsequently investigated as hybrid/dual action drugs and selectively targeted against convulsion.

Keywords: Anticonvulsant, docking, isatin, MES, sc-PTZ, epilepsy.

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Article Details

Year: 2018
Published on: 18 July, 2018
Page: [76 - 101]
Pages: 26
DOI: 10.2174/1871524917666171113124112
Price: $65

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