Ganoderma lucidum Polysaccharides as An Anti-cancer Agent

Author(s): Didem Sohretoglu, Shile Huang*

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 18 , Issue 5 , 2018

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Graphical Abstract:


The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases and to promote health and longevity. Clinical studies have shown beneficial effects of G. lucidum as an alternative adjuvant therapy in cancer patients without obvious toxicity. G. lucidum polysaccharides (GLP) is the main bioactive component in the water soluble extracts of this mushroom. Evidence from in vitro and in vivo studies has demonstrated that GLP possesses potential anticancer activity through immunomodulatory, anti-proliferative, pro-apoptotic, anti-metastatic and anti-angiogenic effects. Here, we briefly summarize these anticancer effects of GLP and the underlying mechanisms.

Keywords: Ganoderma lucidum polysaccharides, Reishi, anti-cancer, immunomodulatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic.

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Article Details

Year: 2018
Published on: 21 August, 2018
Page: [667 - 674]
Pages: 8
DOI: 10.2174/1871520617666171113121246
Price: $65

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