Background: The pathological diagnostic criteria for Alzheimer's disease (AD) updated by
the National Institute on Aging-Alzheimer's Association (NIA-AA) in 2012 has been widely adopted,
but the clinicopathological relevance remained obscure in Chinese population.
Objective: This study aims to investigate the correlations between the antemortem clinical cognitive performances
and the postmortem neuropathological changes in the aging and AD brains collected in a human
brain bank in China.
Method: A total of 52 human brains with antemortem cognitive status information [Everyday Cognition
(ECog)] were collected through the willed donation program by CAMS/PUMC Human Brain Bank.
Pathological changes were evaluated with the “ABC” score following the guidelines of NIA-AA. The
clinicopathological relationship was analyzed with correlation analysis and general linear multivariate
Results: The general ABC score has a significant correlation with global ECog score (r=0.37, p=0.014)
and most of ECog domains. The CERAD score of neuritic plaques (C score) has a significant correlation
with global ECog score (r=0.40, p=0.007) and the majority of ECog domains, such as memory (r=0.50,
p=0.001), language (r=0.45, p=0.002), visuospatial functions (r=0.31, p=0.040), planning (r=0.35,
p=0.021) and organization (r=0.39, p=0.010). The Braak stage of neurofibrillary tangles (NFTs) (B
score) has a moderate correlation with memory (r=0.32, p=0.035). The Thal phases of amyloid-β (Aβ)
deposits (A score) present no significant correlation with any of ECog domains.
Conclusion: In this study, we verified the correlation of postmortem C and B scores, but not the A score
with cognition performance in a collection of samples from the Chinese human brain bank.