Urea and its derivatives, which are usually generated through the carbonylation reaction between
amines and carbonylation reagent, have been found widespread applications in agriculture and
pharmaceuticals. Among the carbonylation reaction, it is the most appealing and promising strategy
that employs CO2 as a green carbonylation reagent. However, CO2 inherent thermodynamic stability
and kinetic inertness limit its application. Apart from being regarded as one of the green solvents,
ionic liquid is also an efficient organocatalyst for CO2 capture or activation due to the interaction between
CO2 with cation or anion of ionic liquid. In this mini-review, we have summarized representative
synthetic methodologies of urea derivatives using carbon dioxide as a green carbonylation reagent
and using ionic liquids as solvents and/or organocatalysts.
Keywords: Activation, carbon dioxide, carbonylation, ionic liquid, organocatalyst, urea derivatives.
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