Background: The study of the mechanisms of liver regeneration is quite an intriguing field that has been
extensively modeled. Through the process of compensatory proliferation of the hepatocytes, the liver mass is restored
after loss of up to two-thirds of the entire mass. Cyclic nucleotides are intracellular second messengers which
are involved in the transduction of a diverse array of stimuli, mediating metabolic and growth regulation. The relationship
between cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling
and liver regeneration has somehow been elusive to pioneer researchers in the field of liver regeneration. In this
review, we will highlight the mechanistic approach involving cyclic nucleotide signaling and its regulation of cell
cycle progression in proliferating hepatocytes, highlighting its usefulness to devising therapeutic tools for managing
Method: A structured search and review of relevant papers was conducted by the authors.
Results: Authors included forty-two peer-reviewed literature in the review which identified possible roles of cyclic
nucleotides in hepatocyte proliferation.
Conclusion: This review article confirms the biological importance of cyclic nucleotides and the mediatory growth
signaling events that could bring about compensatory proliferation of the liver tissues.