An In Situ Procedure; Grinding Synthesis of 4H-benzo[h]chromene-3- carbonitriles Using DBU-hydrobromide-perbromide

Author(s): Mohammad Nikpassand*, Leila Zare Fekri

Journal Name: Current Green Chemistry

Volume 4 , Issue 2 , 2017


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Abstract:

Background: A clean and environmentally benign route to 4H-benzo[h]chromene-3- carbonitriles has been developed via three-component condensation reaction of various benzyl alcohols, malononitrile and 1-naphthol using DBU-hydrobromide-perbromide as an efficient oxidizing reagent at room temperature.

Methodology: The present methodology offers several advantages such as solvent-free conditions, excellent yields, simple procedure, mild conditions and reduced environmental consequences.

Conclusion: All of synthesized compounds were characterized by IR, NMR and elemental analyses.

Keywords: Chromene, benzyl alcohol, multicomponent reaction, 1-Naphthol, malononitrile, TFE.

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2017
Published on: 11 December, 2017
Page: [103 - 107]
Pages: 5
DOI: 10.2174/2213346104666171031102921
Price: $25

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