4-Acetamidobenzaldehyde Derivatives as Biological Active Candidates; Synthesis, Anti-oxidant, Anti-Alzheimer and DNA Binding Studies

Author(s): Shahzad Murtaza*, Adina Tatheer

Journal Name: Letters in Drug Design & Discovery

Volume 15 , Issue 9 , 2018

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Background: Due to high demand of developing new compounds to solve the health issues, paracetamol resembling 4-acetamidobenzaldehyde was derivatized into different new compounds including important pharmacophores (benzimidazole, benzothiazole). The synthesized compounds were investigated for anti-Alzheimer, antioxidant and DNA binding abilities.

Methods: The new compounds were synthesized by the well-established synthetic routes. All synthesized compounds were analysed by H-NMR, 13C-NMR, Mass spectrometry and FTIR. Spectrophotometric method was applied for determination of inhibition potency against AChE and BChE. DPPH free radical scavenging method was used to check the antioxidant ability and the spectrophotometric titration was utilized to study the binding ability of synthesized derivatives with DNA.

Results: 4-Acetamdiobenzaldehyde based derivatives were synthesized and characterised by HNMR, 13C-NMR, Mass spectrometry and FTIR. The synthesized compounds were analysed for anti-Alzheimer activity and results were compared by docking showed that 18 and 2 are good inhibitors of AChE and BChE. The results of DPPH radical scavenging activity explored most of the synthesized compounds as good antioxidants, out of these 18 showed maximum scavenging activities. Furthermore, compound 2 exhibited maximum intrinsic binding constant (K= 9.64×105M-1) for DNA.

Conclusion: A new series of 4-Acetamidobenzaldehyde derivatives (1-20) were synthesized, characterized and studied for their antioxidant, anti-Alzheimer and DNA binding abilities. The results of anti-Alzheimer activity were compared by docking. Most of the synthesized compounds showed very significant antioxidants, anti-cholinesterase activities. All the compounds showed weak interaction with the DNA. These compounds are suitable for further pharmacological investigations.

Keywords: Schiff base, benzimidazole, benzothiazole, antioxidant, enzyme inhibition, DNA-interaction, molecular docking.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2018
Published on: 26 October, 2017
Page: [957 - 968]
Pages: 12
DOI: 10.2174/1570180814666171026161646
Price: $65

Article Metrics

PDF: 24
PRC: 1