Background: Common childhood neuropsychiatric disorders are treated with multiple
categories of psycho-active agents. Adverse side effects of psychotropic pharmacotherapeutics
range from expected neuro-psychiatric changes to allergic reactions and immunologic
Objective: This review focuses on the immune system effects of common categories of medications
used to treat neuro-psychiatric and behavioral disorders.
Method: Narrative review of literature using PubMed database up to May 10, 2017.
Results: Multiple neuro- and psycho-tropic medication classes are found to influence the function
of the immune system in various ways, both in the direction of immune suppression and immune
Conclusion: Immunologic activity of these medications in the frame-work of now wellestablished
role of inflammation in neuro-psychiatric diseases should continue to be defined.
At the same time, clinicians are advised to pay attention to potentially detrimental immune
suppression that may be associated with some of these medications, and consider iatrogenic
etiology in patients presenting with undue susceptibility to infection.