Furan-induced Oxidative Stress and DNA Damage in Diabetic and Nondiabetic Rats’ Blood and Protective Effect of Lycopene

Author(s): Dilek Pandir*

Journal Name: Current Nutrition & Food Science

Volume 14 , Issue 4 , 2018

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Graphical Abstract:


Aim: This study aims to determine the adverse effect of furan in terms of oxidative stress parameters, DNA damage and the formation of micronucleus (MN) on experimental diabetic and nondiabetic rat’s blood and protective potency of the lycopene.

Methods: In the current study, fifty six adult wistar albino male rats were divided into eight groups of seven rats in each. 28 days after the application, biochemical (SOD, CAT, GPx, MDA) changes with trolox equivalent antioxidant capacity (TEAC) and ferric reducing antioxidant power (FRAP), DNA damage and formation of MN as well as membran structure of erythrocytes in the blood tissue samples were studied. Leucocytes were used for DNA damage with comet assay.

Results: Furan has been adverse effect on antioxidant enzyme systems and MDA level of erythrocytes and leucocytes, decreased TEAC and FRAP values, increased DNA damage, MN and deteriorated cells’ morphology in non-diabetic rat’s blood. These changes were seen in diabetes treatment groups, too. The results shown that the administration of lycopene could have a harmful efficiency against treatment with furan in the diabetic and non-diabetic rat’s blood.

Conclusion: It was seen that antioxidant enzymes activities, TEAC and FRAP values increased, the levels of MDA, tail DN%, mean tail length and MN decreased and improved membrane structure in the blood cells. Also, these data shown that the lycopene has more protective effects in erythrocytes and leucocytes of non-diabetic groups than diabetic groups.

Keywords: Blood tissue, DNA damage, furan, lycopene, micronucleus, oxidative stress.

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Article Details

Year: 2018
Published on: 04 July, 2018
Page: [358 - 368]
Pages: 11
DOI: 10.2174/1573401313666171016160652
Price: $65

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