Aim: This study aims to determine the adverse effect of furan in terms of oxidative stress
parameters, DNA damage and the formation of micronucleus (MN) on experimental diabetic and nondiabetic
rat’s blood and protective potency of the lycopene.
Methods: In the current study, fifty six adult wistar albino male rats were divided into eight groups of
seven rats in each. 28 days after the application, biochemical (SOD, CAT, GPx, MDA) changes with
trolox equivalent antioxidant capacity (TEAC) and ferric reducing antioxidant power (FRAP), DNA
damage and formation of MN as well as membran structure of erythrocytes in the blood tissue samples
were studied. Leucocytes were used for DNA damage with comet assay.
Results: Furan has been adverse effect on antioxidant enzyme systems and MDA level of erythrocytes
and leucocytes, decreased TEAC and FRAP values, increased DNA damage, MN and deteriorated
cells’ morphology in non-diabetic rat’s blood. These changes were seen in diabetes treatment groups,
too. The results shown that the administration of lycopene could have a harmful efficiency against
treatment with furan in the diabetic and non-diabetic rat’s blood.
Conclusion: It was seen that antioxidant enzymes activities, TEAC and FRAP values increased, the
levels of MDA, tail DN%, mean tail length and MN decreased and improved membrane structure in
the blood cells. Also, these data shown that the lycopene has more protective effects in erythrocytes
and leucocytes of non-diabetic groups than diabetic groups.