Tissue Engineering Approaches for Building Cardiac Tissue
Pp. 121-162 (42)
Rachel Hatano and Kara E. McCloskey
Following a myocardial infarction, the nutrient deprived areas of the heart
become ischemic scar tissue. Moreover, the heart can deteriorate further over time,
eventually leading to heart failure. The need for strategies for repair/regeneration of
heart tissue is undisputed, and many interdisciplinary teams of researchers have
examined the roles of signals found in the biochemical, material, mechanical, and
electrical niche of the heart in order to direct cardiac cell fate from stem cells and/or
develop strategies for the repair and/or replacement of the damaged heart tissue. This
chapter will explore the diversity of techniques recently used for: deriving cardiac cells
from pluripotent cell sources, organizing and building cardiomyocyte tissue, examining
the long-term cell/tissue engraftment, and correlating improvements in cardiac tissue
Cardiac tissue engineering, Cardiomyocytes, Cardiovascular repair,
Cell patterning, Stem cell differentiation.
School of Engineering, University of California, Merced, CA, USA.