Frontiers in Stem Cell and Regenerative Medicine Research

Frontiers in Stem Cell and Regenerative Medicine Research

Volume: 7

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to ...
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Tissue Engineering Approaches for Building Cardiac Tissue

Pp. 121-162 (42)

Rachel Hatano and Kara E. McCloskey

Abstract

Following a myocardial infarction, the nutrient deprived areas of the heart become ischemic scar tissue. Moreover, the heart can deteriorate further over time, eventually leading to heart failure. The need for strategies for repair/regeneration of heart tissue is undisputed, and many interdisciplinary teams of researchers have examined the roles of signals found in the biochemical, material, mechanical, and electrical niche of the heart in order to direct cardiac cell fate from stem cells and/or develop strategies for the repair and/or replacement of the damaged heart tissue. This chapter will explore the diversity of techniques recently used for: deriving cardiac cells from pluripotent cell sources, organizing and building cardiomyocyte tissue, examining the long-term cell/tissue engraftment, and correlating improvements in cardiac tissue function.

Keywords:

Cardiac tissue engineering, Cardiomyocytes, Cardiovascular repair, Cell patterning, Stem cell differentiation.

Affiliation:

School of Engineering, University of California, Merced, CA, USA.