Novel Hybrid Molecules of Quinazoline Chalcone Derivatives: Synthesis and Study of in vitro Cytotoxic Activities

Author(s): Arunkumar Thiriveedhi*, Ratnakaram Venkata Nadh, Navuluri Srinivasu, Kishore Kaushal

Journal Name: Letters in Drug Design & Discovery

Volume 15 , Issue 7 , 2018

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Graphical Abstract:


Background: A new series of quinazoline linked chalcone conjugates were synthesized and evaluated for their in vitro cytotoxicity.

Methods: The quinazoline-chalcone derivatives (13a-r) have been prepared by the Claisen-Schmidt condensation of various substituted benzaldehydes (12a-r) with substituted l-(4-(3,4- dihydroquinazolin-4-ylamino)phenyl)ethanone (11a-b) in the presence of aqueous NaOH. Three potential compounds 13f, 13g and 13h exhibited cytotoxicity against leukemia (GI50 value of 1.07, 0.26 and 0.24 µM), Non-small lung (GI50 values of 2.05,1.32 and 0.23 µM), colon (GI50 values of 0.54, 0.34 and 0.34 µM) and breast (GI50 values of 2.17, 1.84 and 0.22 µM) cell line, respectively.

Results and Conclusion: Based on these biological results, it is evident that compound 13h has the potential to be considered for further detailed studies either alone or in combination with existing therapies as potential anticancer agents.

Keywords: In vitro, cytotoxic studies, hybrid molecules, quinazolines, chalcone derivatives, potential anticancer agents.

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Article Details

Year: 2018
Page: [757 - 765]
Pages: 9
DOI: 10.2174/1570180814666171013162148
Price: $65

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