Title:Triazino-caffeine Derivatives by Intramolecular Cyclization: Synthesis, Characterization and Antimicrobial Studies
VOLUME: 15 ISSUE: 6
Author(s):A.B. Reddy*, R.V. Hymavathi, G.N. Swamy and E.R. Sadiku
Affiliation:Department of Chemical, Metallurgical and Materials Engineering, Tshwane University of Technology, Pretoria Campus, Building 2, Pretoria, Department of Bio-Chemistry, Sri Krishnadevaraya University, Anantapur 515003, Andhra Pradesh, Department of Chemistry, Sri Krishnadevaraya University, Anantapur 515003, Andhra Pradesh, Department of Chemical, Metallurgical and Materials Engineering, Tshwane University of Technology, Pretoria Campus, Building 2, Pretoria
Keywords:Triazino-caffeine derivatives, Mitsunobu reaction, intramolecular cyclization, antimicrobial activities, morpholine
moiety, heterocycles.
Abstract:In the present study, a new class of triazino-caffeine derivatives with good antimicrobial
activities is reported. Eight new triazino-caffeine derivatives were synthesized via Mitsunobu reaction,
followed by intramolecular cyclization. Their chemical structures were established on the basis of
elemental analysis, IR, 1H NMR, mass spectral data as well as through an alternate synthetic route. The
compounds were also screened for their antimicrobial activities, among them, compounds 5c and 5d
showed good inhibitory potentials, indicating the importance of morpholine moiety in enhancing
antimicrobial activity. Therefore, it is concluded that the triazino-caffeine derivatives developed, show
encouraging potentials in their medicinal applications.
