Background: Gastroesophageal reflux disease (GERD) is one of the most
common diseases in society, affecting up to 40% of the population. It has major impact
on the quality of life and a high burden on medical expenditure. In this work,
herbs used by ancient Iranians to treat GERD have been introduced.
Methods: Different well-known Persian textbooks and recent electronic databases
were searched to explore the treatment of GERD and the pharmacological mechanisms
of the identified medicinal plants.
Results: GERD has been known for many centuries, and many herbal remedies for
its treatment have been elucidated in traditional medical literature. We found 25 medicinal
herbs in Persian medicine books and searched for evidence to support them in
the current literature.
Conclusion: Although their active components or the mechanism of action were not
known by the ancient Persians at that time, their persistent use during different centuries
might indicate their effectiveness. Owing to their potential, medicinal herbs are a
viable option for the treatment of diseases like GERD even today.