Abstract
Inflammatory bowel disease (IBD) is an uncontrolled chronic inflammatory intestinal disorder, which requires medications for long-term therapy. Facing the challenges of severe side effects and drug resistance of conventional medications, to develop the strategies meet the stringent safety and effectiveness in the long-term treatment are urgent in the clinics. In this regard, a growing body of evidence confirms plant-sourced phenols, such as flavonoids, catechins, stilbenes, coumarins, quinones, lignans, phenylethanoids, cannabinoid phenols, tannins, phenolic acids and hydroxyphenols, exert potent protective benefits with fewer undesirable effects in conditions of acute or chronic intestinal inflammation through improvement of colonic oxidative and pro-inflammatory status, preservation of the epithelial barrier function and modulation of gut microbiota. In this review, the great potential of plant-sourced phenols and their action mechanisms for the treatment or prevention of IBD in recent research are summarized, which may help further development of new preventive/adjuvant regimens for IBD.
Keywords: Inflammatory bowel disease, plant-sourced phenols, therapeutic effects, action mechanism, ulcerative colitis, Crohn's disease, colonic tissue edema.
Current Medicinal Chemistry
Title:Potential of Plant-sourced Phenols for Inflammatory Bowel Disease
Volume: 25 Issue: 38
Author(s): Hai-tao Xiao, Bo Wen, Xiang-chun Shen*Zhao-xiang Bian*
Affiliation:
- The Key Laboratory of Pharmacology and Druggability for Natural Medicines of Department of Education, Guizhou Province, Guizhou Medical University, 550025 Guizhou,China
- School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon,Hong Kong
Keywords: Inflammatory bowel disease, plant-sourced phenols, therapeutic effects, action mechanism, ulcerative colitis, Crohn's disease, colonic tissue edema.
Abstract: Inflammatory bowel disease (IBD) is an uncontrolled chronic inflammatory intestinal disorder, which requires medications for long-term therapy. Facing the challenges of severe side effects and drug resistance of conventional medications, to develop the strategies meet the stringent safety and effectiveness in the long-term treatment are urgent in the clinics. In this regard, a growing body of evidence confirms plant-sourced phenols, such as flavonoids, catechins, stilbenes, coumarins, quinones, lignans, phenylethanoids, cannabinoid phenols, tannins, phenolic acids and hydroxyphenols, exert potent protective benefits with fewer undesirable effects in conditions of acute or chronic intestinal inflammation through improvement of colonic oxidative and pro-inflammatory status, preservation of the epithelial barrier function and modulation of gut microbiota. In this review, the great potential of plant-sourced phenols and their action mechanisms for the treatment or prevention of IBD in recent research are summarized, which may help further development of new preventive/adjuvant regimens for IBD.
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Cite this article as:
Xiao Hai-tao , Wen Bo , Shen Xiang-chun*, Bian Zhao-xiang*, Potential of Plant-sourced Phenols for Inflammatory Bowel Disease, Current Medicinal Chemistry 2018; 25 (38) . https://dx.doi.org/10.2174/0929867324666171009100900
DOI https://dx.doi.org/10.2174/0929867324666171009100900 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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