Background: Alkaloids are a diverse group of naturally occurring secondary
metabolites which exhibit various pharmacological properties. They have been synthesized
via various synthetic routes in order to study their medicinal efficacy and structure
Methodology: Keeping in view the pharmaceutical significance of this class of compounds,
the present review has been written with a focus on the synthetic approaches used
for efficient construction of isoquinoline scaffolds in natural alkaloids including crispine
A, emetine, erythrocarine, jamatine, annosqualine, morphine, lemonomycin, papaverine,
berberine, and codeine.
Conclusion: The main goal behind the compilation of these schemes is to inspire organic
chemists and help reinvigorate the development of novel strategies for the synthesis of isoquinoline alkaloids
and their derivatives in the future.