Nanoprecipitation for Poorly Water-Soluble Drugs

Author(s): Tuong N.G. Nguyen, Van-Thanh Tran, Wei Duan, Phuong H.L. Tran, Thao T.D. Tran*

Journal Name: Current Drug Metabolism

Volume 18 , Issue 11 , 2017

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Graphical Abstract:


Background: More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects.

Methods: Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up.

Results: However, there are two technical issues of concern related to this method. First, the two solvents used for this approach must be miscible; concomitantly, the drug has to be soluble enough in a solvent but not in the antisolvent. Second, the particle growth needs to be adjusted by surfactant addition.

Conclusion: In this review, nanoprecipitation methods and solvent removal techniques for poorly water soluble drugs will be discussed.

Keywords: Nanoprecipitation, poorly water-soluble drug, solvent removal technique, surfactant, anti-solvent, nanoparticulate.

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Article Details

Year: 2017
Published on: 17 January, 2018
Page: [1000 - 1015]
Pages: 16
DOI: 10.2174/1389200218666171004112122
Price: $65

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PDF: 28
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