Synthesis and Mosquitocidal Activity of a Series of Hydrazone Derivatives against Aedes aegypti

Author(s): Mehlika Dilek Altintop*, Nurhayat Tabanca, James J. Becnel, Jeffrey R. Bloomquist, Zafer Asim Kaplancikli, Ahmet Ozdemir

Journal Name: Letters in Drug Design & Discovery

Volume 15 , Issue 6 , 2018

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Graphical Abstract:


Background: Aedes aegypti is an important mosquito vector for the transmission of several infectious diseases. Current insecticides play a vital role in controlling mosquitoes; however, the frequent use of insecticides has led to the development of insecticide resistance. In order to control mosquito populations, new and effective bioactive molecules are urgently needed.

Methods: In the current work, N-(benzylidene)-3-cyclopentylpropionic acid hydrazide derivatives (2a-p) were synthesized and evaluated for their larvicidal and adulticidal effects on Ae. aegypti.

Results: N-(Benzylidene)-3-cyclopentylpropionic acid hydrazide (2a) and N-(4-isopropylbenzylidene)- 3-cyclopentylpropionic acid hydrazide (2i) were identified as the most potent larvicides in this series with LC50 values of 0.0097 (0.005-0.017, 95%CI) µg/µL and 0.2729 (0.223- 0.336, 95%CI) µg/µL, respectively against 1st instar A. aegypti. On the other hand, compounds 2a-p showed weak adulticidal activity against adult female A. aegypti.

Conclusion: Due to their notable larvicidal activity, compounds 2a and 2i stand out as promising candidates for further studies.

Keywords: Hydrazone, mosquito control, insecticidal activity, dengue fever, Zika virus, larvicidal effects.

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Article Details

Year: 2018
Page: [671 - 677]
Pages: 7
DOI: 10.2174/1570180814666171002155548
Price: $65

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