Background: Aedes aegypti is an important mosquito vector for the transmission of
several infectious diseases. Current insecticides play a vital role in controlling mosquitoes;
however, the frequent use of insecticides has led to the development of insecticide resistance. In
order to control mosquito populations, new and effective bioactive molecules are urgently needed.
Methods: In the current work, N-(benzylidene)-3-cyclopentylpropionic acid hydrazide derivatives
(2a-p) were synthesized and evaluated for their larvicidal and adulticidal effects on Ae. aegypti.
Results: N-(Benzylidene)-3-cyclopentylpropionic acid hydrazide (2a) and N-(4-isopropylbenzylidene)-
3-cyclopentylpropionic acid hydrazide (2i) were identified as the most potent larvicides
in this series with LC50 values of 0.0097 (0.005-0.017, 95%CI) µg/µL and 0.2729 (0.223-
0.336, 95%CI) µg/µL, respectively against 1st instar A. aegypti. On the other hand, compounds 2a-p
showed weak adulticidal activity against adult female A. aegypti.
Conclusion: Due to their notable larvicidal activity, compounds 2a and 2i stand out as promising
candidates for further studies.