In this paper, first graphene oxide catalyzed one-pot three-component green synthesis of 1,3-
thiazolidin-4-one using amine, aldehyde and mercapto acetic acid in water has been reported. The reaction
is affected via sequential C-N and C-S bond formation and ring transformation reactions leading to
thiazolidin-4-ones formation. The use of water as solvent at room temperature, good to excellent yields
of pure products (75-92%) and operational simplicity are the salient features of the envisaged protocol.
The graphene oxide catalyst is very mild, effective and most of its activity is preserved after being reused
for five times.
Keywords: Graphene oxide, imine, mercaptoacetic acid, 1, 3-thiazolidin-4-one, water, organic.
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