Graphene Oxide Catalyzed C-N/C-S/[3+2] Cyclization Cascade for Green Synthesis of Thiazolidinone in Water

Author(s): Suhasini Mahata, Anjumala Sahu, Prashant Shukla, Ankita Rai, Manorama Singh, Vijai K. Rai*

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 8 , 2018

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Graphical Abstract:


In this paper, first graphene oxide catalyzed one-pot three-component green synthesis of 1,3- thiazolidin-4-one using amine, aldehyde and mercapto acetic acid in water has been reported. The reaction is affected via sequential C-N and C-S bond formation and ring transformation reactions leading to thiazolidin-4-ones formation. The use of water as solvent at room temperature, good to excellent yields of pure products (75-92%) and operational simplicity are the salient features of the envisaged protocol. The graphene oxide catalyst is very mild, effective and most of its activity is preserved after being reused for five times.

Keywords: Graphene oxide, imine, mercaptoacetic acid, 1, 3-thiazolidin-4-one, water, organic.

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Article Details

Year: 2018
Published on: 02 July, 2018
Page: [665 - 672]
Pages: 8
DOI: 10.2174/1570178614666171002145250
Price: $65

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