A Review of the Pharmacological Properties of 3,4-dihydro-2(1H)- quinolinones

Author(s): Letitia Meiring, Jacobus P. Petzer, Anel Petzer*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 10 , 2018

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Graphical Abstract:


The 3,4-dihydro-2(1H)-quinolinone moiety is present in a number of pharmacologically active compounds. These include FDA approved drugs such as cilostazol, carteolol and aripiprazole as well as numerous experimental compounds. Compounds containing the 3,4-dihydro-2(1H)-quinolinone moiety also exhibit a variety of activities in both the peripheral and central tissues, which includes phosphodiesterase inhibition, blocking of β-adrenergic receptors, antagonism of vasopressin receptors and interaction with serotonin and dopamine receptors. Based on its versatility in drug design and action, this paper reviews the pharmacological actions of compounds containing the 3,4-dihydro-2(1H)- quinolinone scaffold with emphasis being placed on the most important and significant members of each activity class.

Keywords: Aripiprazole, carteolol, cilostazol, 3, 4-dihydro-2(1H)-quinolinone, pharmacology, drug design.

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Article Details

Year: 2018
Published on: 30 April, 2018
Page: [828 - 836]
Pages: 9
DOI: 10.2174/1389557517666170927141323
Price: $65

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