Recent Advances in the Discovery and Development of Marine Natural Products with Cardiovascular Pharmacological Effects

Author(s): Jie-Bin Zhou, Rong Luo, Ying-Lin Zheng, Ji-Yan Pang*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 6 , 2018

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Abstract:

Numerous studies have indicated that marine natural products are one of the most important sources of the lead compounds in drug discovery for their unique structures, various bioactivities and less side effects. In this review, the marine natural products with cardiovascular pharmacological effects reported after 2000 will be presented. Their structural types, relevant biological activities, origin of isolation and information of strain species will be discussed in detail. Finally, by describing our studies as an example, we also discuss the chances and challenges for translating marine-derived compounds into preclinical or clinical trials.

Keywords: Marine, natural products, discovery, cardiovascular, pharmacology, marine polysaccharide.

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Article Details

VOLUME: 18
ISSUE: 6
Year: 2018
Page: [527 - 550]
Pages: 24
DOI: 10.2174/1389557517666170927112621
Price: $65

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