Numerous studies have indicated that marine natural products are one of the most important
sources of the lead compounds in drug discovery for their unique structures, various bioactivities and
less side effects. In this review, the marine natural products with cardiovascular pharmacological effects
reported after 2000 will be presented. Their structural types, relevant biological activities, origin
of isolation and information of strain species will be discussed in detail. Finally, by describing our
studies as an example, we also discuss the chances and challenges for translating marine-derived compounds
into preclinical or clinical trials.