Diagnosis and Treatment of Drug-Resistant Tuberculosis: State of the Art

Title:Diagnosis and Treatment of Drug-Resistant Tuberculosis: State of the Art

Volume: 13 Issue: 2

Author(s): Rafael Laniado-Laborin*

Affiliation:

• Clinica y Laboratorio de Tuberculosis, Hospital General Tijuana, Ave. Centenario 10851, Zona Rio, Tijuana Baja California, CP 22320,Mexico

Keywords: Advances, diagnosis, drug-resistant, in-vitro, treatment, tuberculosis.

Abstract: Background: For decades there were no significant advances in the development of diagnostic procedures for drug resistant TB (DR-TB), or the availability of new, effective drugs specifically developed for DR-TB. Now, we have witnessed during the last decade, the arrival of several new diagnostic techniques and new drugs, already available for clinical use. This review aims to critically analyze evidence-based recommendations on the most recent developments in the diagnosis and treatment of multidrug-resistant tuberculosis (MDR.TB).

Methods: PubMed search for papers describing innovative diagnostic techniques and newer drugs and treatment regimens for MDR-TB. All World Health Organization (WHO) evidence-based guidelines on the subject of diagnostic techniques and new drugs and treatment regimens were also reviewed.

Results: 21 papers, 10 WHO guidelines and one Global Tuberculosis Report (2016) were included in the review. Nineteen were original papers on diagnostic techniques or newer drugs and 2 were editorials on the global burden of MDR-TB. One WHO global report dealt with the burden of MDRTB, 6 guidelines had evidence-based recommendations on newer diagnostic techniques for MDR-TB and 4 had evidence based recommendations on new drugs and treatment regimens for MDR-TB.

Conclusion: The findings of this review confirm that genotypic diagnostic methods have revolutionized the diagnosis of MDR-TB, from a process that used to take months to one that now takes just a few hours. Also, for the first time in more than 50 years, two new antituberculosis drugs, delamanid and bedaquiline, are now added to the armamentarium, a greatly needed alternative for the treatment of MDR-TB.

Cite this article as:

Laniado-Laborin Rafael *, Diagnosis and Treatment of Drug-Resistant Tuberculosis: State of the Art, Current Respiratory Medicine Reviews 2017; 13 (2) . https://dx.doi.org/10.2174/1573398X13666170926154425