The Role of Dietary Compounds in the Therapy of Nicotine-Induced Osteoporosis

Author(s): Norazlina Mohamed*, Norliza Muhammad, Ahmad Nazrun Shuid, Ima-Nirwana Soelaiman

Journal Name: Current Drug Targets

Volume 19 , Issue 12 , 2018

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Graphical Abstract:


Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts negative effects on bone. The number of people who smoke increases each day. Those who smoke start at a very young age and they usually smoke for years. This will increase the risk of developing osteoporosis. As the prevalence of osteoporosis increases, the risk of fractures also increases. The major concerns are disability following fractures, mortality due to complications after fractures and the increasing cost of management and therapy. This paper will review the effects of nicotine on bone and the potential natural products which can be used as treatment for nicotine-induced osteoporosis.

Keywords: Vitamin E, vitamin C, flavonoids, polyphenols, nicotine, smoking, osteoporosis.

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Article Details

Year: 2018
Published on: 13 August, 2018
Page: [1424 - 1430]
Pages: 7
DOI: 10.2174/1389450118666170925154428
Price: $65

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PDF: 29