Background and Objective: Increasing evidence has demonstrated that dietary products and
their active components are independently or jointly responsible for the apparent reduction of the cardiovascular
diseases (CVDs) risk.
Discussion: Nowadays, there is a growing attention in the use of nutraceuticals as a new approach for
the prevention and management of many diseases, as well as for controlling rising of chronic illnesses
with minimal side effects. Food-derived peptides, as well as peptide-rich protein hydrolysates, represent
new and valuable tools for the prevention of metabolic and cardiovascular diseases, acting as
modulators of oxidative stress, inflammation, and overactivity of the renin–angiotensin system (RAS).
Conclusion: This review summarizes the recently published data on antioxidant, anti-inflammatory,
and vascular protective properties of nutraceuticals, notably on the effects of food-derived bioactive
peptides and protein hydrolysates, paying particular attention to those derived from fermented foods.