Insights into the Association of Vitamin D Deficiency with Parathyroid Hormone Levels with Relevance to Renal Function and Insulin Resistance

Author(s): Iyyapu K. Mohan*, Siraj A. Khan, Rachel Jacob, Kompella S.S.S. Baba, Tajamul Hussain, Salman A. Alrokayan, Shaik Mohammad Naushad

Journal Name: Current Nutrition & Food Science

Volume 15 , Issue 2 , 2019

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Graphical Abstract:


Background: In majority of the studies inverse association between vitamin D and parathyroid hormone levels is documented.

Objective: The rationale of the current study was to investigate whether this inverse association is agedependent and whether it has any role in modulating renal function and insulin resistance.

Methods: To test this hypothesis, we have carried out a hospital based study enrolling 848 subjects (558 men and 290 women) with the mean age of 50.9 ± 15.9 y. Chemiluminometric competitive immune assays were performed using commercial kits to determine 25-OH vitamin D and Parathyroid Hormone (PTH) levels. Fasting glucose levels and serum creatinine were used to evaluate diabetes and renal function.

Results: Vitamin D deficiency was predominant irrespective of age group (p = 0.21) and gender (p = 0.12). An inverse association between vitamin D and PTH was observed (r = -0.24) in middle age subjects (p = 0.02). The data segregation based on plasma vitamin D levels which were <20 ng/ml, 20.1- 30 ng/ml and >30 ng/ml confirmed the inverse association between vitamin D and PTH levels (ptrend: 0.007). Subjects with low plasma vitamin D and increased PTH exhibited elevated blood urea, serum creatinine and blood glucose. Subjects with 25-OHD deficiency showed a 3.03-folds (95% CI: 2.26- 4.07) and 2.09-fold (1.41-3.10) increased risk for diabetes and renal disease, respectively.

Conclusion: Based on the results of the present study, it is suggested that those with vitamin D deficiency need to be evaluated for possible presence of renal dysfunction, diabetes/insulin resistance in addition to assessing their PTH status.

Keywords: Diabetes, hyperparathyroidism, insulin resistance, parathyroid hormone, vitamin D, serum creatinine.

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Article Details

Year: 2019
Published on: 21 March, 2019
Page: [196 - 200]
Pages: 5
DOI: 10.2174/1573401313666170920145038
Price: $65

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