Abstract
Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic complications. Here we summarize the current knowledge on the role of apelin in the pathogenesis of different diabetic complications. We also propose that similar to insulin resistance or leptin resistance, diabetics may also show apelin resistance. Potential clinical application of apelin and its analogue peptides in treating diabetic complications is discussed.
Keywords: Apelin, adipokine, diabetes, diabetic complications, metabolic disorder, cardiomyopathy.
Current Protein & Peptide Science
Title:Effects of Apelin Peptides on Diabetic Complications
Volume: 19 Issue: 2
Author(s): Hong Chen, Chengyu Liu, Cheng Cheng, Ling Zheng and Kun Huang*
Affiliation:
- Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030,China
Keywords: Apelin, adipokine, diabetes, diabetic complications, metabolic disorder, cardiomyopathy.
Abstract: Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic complications. Here we summarize the current knowledge on the role of apelin in the pathogenesis of different diabetic complications. We also propose that similar to insulin resistance or leptin resistance, diabetics may also show apelin resistance. Potential clinical application of apelin and its analogue peptides in treating diabetic complications is discussed.
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Cite this article as:
Chen Hong , Liu Chengyu , Cheng Cheng , Zheng Ling and Huang Kun *, Effects of Apelin Peptides on Diabetic Complications, Current Protein & Peptide Science 2018; 19 (2) . https://dx.doi.org/10.2174/1389203718666170918154728
DOI https://dx.doi.org/10.2174/1389203718666170918154728 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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