Cardiovascular Drug Therapy for Human Newborn: Review of Pharmacodynamic Data

Author(s): Ebru Ergenekon, Hector Rojas-Anaya, Maria Carmen Bravo, Charalampos Kotidis, Liam Mahoney, Heike Rabe*

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 38 , 2017

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Background: Circulatory failure in preterm and term newborn infants is commonly treated with inotropes or vasoactive medications. In this structured literature review, the available data on pharmacodynamic effects of the inotropes adrenaline, dobutamine, dopamine, levosimendan, milrinone, noradrenaline, and the vasoactive drugs vasopressin and hydrocortisone are presented.

Methods: Structured searches were conducted to identify relevant articles according to pre-defined inclusion criteria which were human clinical trials published after 2000.

Results: Out of 101 identified eligible studies only 22 studies met the criteria for evidence based practice guidelines level I to IV. The most prevalent pharmacodynamic effects were increase in blood pressure and/or heart rate, which were also the most frequently studied circulatory parameters.

Conclusion: This review demonstrates the need for further systematic studies on all reviewed drugs with incorporation of novel non-invasive biomarkers in this vulnerable patient group, for more timely and appropriate treatment for clinical efficacy.

Keywords: Cardiac, circulation, inotrope, pharmacodynamic, neonate, preterm.

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Article Details

Year: 2017
Published on: 09 February, 2018
Page: [5850 - 5860]
Pages: 11
DOI: 10.2174/1381612823666170918122755
Price: $65

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