Background: Heterocycles containing thiazole, a moiety with sulfur and
nitrogen is a core structure which is found in a number of biologically active compounds.
The thiazole ring is notable as a component of the certain natural products,
such as vitamin B1 (thiamine) and penicillins. Thiazole is also known as wonder nucleus
and has uses in different biological fields. A number of new compounds contain
heterocycle thiazole moieties, thus it is one of the important areas of research.
Methods: We searched the scientific database using relevant keywords. Among the
searched literature only peer-reviewed papers were collected which addresses our
questions. The retrieved quality research articles were screened and analyzed critically.
The key findings of these studies were included along with their importance.
Results: The quality research articles included in this review were selected for the lifethreatening
diseases i.e. diabetes, which is one of the serious issues all over the globe
with an estimated worldwide prevalence in 2016 of 422 million people, which is expected
to rise double to by 2030. Since 1995, there has been an explosion of the introduction
of new classes of pharmacological agents having thiazole moieties. However,
most of the drugs can cause noncompliance, hypoglycemia, and obesity. Thus, new
antidiabetic drugs with thiazole moieties came up with improved compliance and reduced
side effects such as pioglitazone (Actos), rosiglitazone (Avandia), netoglitazone,
DRF-2189, PHT46, PMT13, DRF-2519. With such a great importance, research in thiazole
is part of many academic and industrial laboratories worldwide.
Conclusion: The present review describes the importance of thiazole nucleus and its
derivatives as antidiabetic agents with an emphasis on the past as well as recent developments.