Abstract
Background: The use of laser methods to irradiate currently used drugs in order to obtain photo-products with antimicrobial and anti-tumour activity constitutes a new approach in fighting antimicrobial resistance acquired by bacteria and tumours.
Methods: The interaction of UV laser radiation with phenothiazine derivatives, such as chlorpromazine, thioridazine and promethazine, and a hydantoin derivative, SZ-2, was evaluated using analytical techniques: UV-Vis-NIR absorption, FTIR, and laser induced florescence.
Results: The investigation of photo-products mixtures suggested the photo-generation of sulfoxide and hydroxyl compounds when phenothiazine derivatives were irradiated and the braking of molecule and detachment of radical attached to thio-hydantoin ring when SZ-2 was irradiated. As for application of laser irradiated drug solutions on pseudo-tumours induced in rabbit eyes using Schmidt-Erfurth method, it was observed a decrease of inflammations related to pseudo-tumours and a fast recovery of corneal tissues.
Conclusion: The best effect concerning the recuperation of healthy corneal tissue quality in the pseudo-tumour was observed for 10 mg/mL chlorpromazine irradiated 20 min with 266 nm laser beam. This new method offers the possibility to combat antimicrobial resistance acquired by tumours or bacteria by flexible development of new agents using laser systems and techniques.
Keywords: Corneal tissue, eye pseudotumour, hydantion, laser induced fluorescence, laser irradiation, multiple drug resistance, phenothiazines, SZ-2, photo-degradation.
Graphical Abstract
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Computer-Aided Drug Design
Current Bioactive Compounds
Current Cancer Drug Targets
Combinatorial Chemistry & High Throughput Screening
Current Cancer Therapy Reviews
Current Diabetes Reviews
Current Drug Safety
Current Drug Targets
Related Books
Drug Addiction Mechanisms in the Brain
Software and Programming Tools in Pharmaceutical Research
Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep
Medicinal Chemistry of Drugs Affecting Cardiovascular and Endocrine Systems
Medicinal Plants, Phytomedicines and Traditional Herbal Remedies for Drug Discovery and Development against COVID-19
Advanced Pharmacy
Plant-derived Hepatoprotective Drugs
The Role of Chromenes in Drug Discovery and Development
New Avenues in Drug Discovery and Bioactive Natural Products
Practice and Re-Emergence of Herbal Medicine
16
2