Background: Honey is known for its therapeutic properties from ancient civilizations. Recently, the
mechanism of action of Manuka honey in wound healing, epithelial regeneration, and ulcer treatments has been
Objective: In the current review, the health perspectives of honey, its chemical composition with special reference to
flavonoids, polyphenol, and other bioactive trace compounds used in tissue regeneration have been discussed in
Methods: We undertook a structured search using wide spectrum sources like Google Scholar, PubMed, and Scopus.
Results: The included papers showed that Manuka honey can inhibit the process of carcinogenesis by controlling
different molecular processes, and progression of cancer cells. Manuka honey has been found to have various
biological activities, including antioxidant, antimicrobial and anti-proliferative capacities. Scientists try to use
Manuka honey in the area of tissue engineering to design a template for regeneration. Naturally derived antibacterial
agents of Manuka honey are numerous mixtures of different compounds, which can influence antibacterial capacity.
The non-peroxide bacteriostatic properties of Manuka honey are associated with the presence of methylglyoxal
Conclusion: In addition to bacterial growth inhibition, glyoxal (GO) and MGO from Manuka honey can enhance
wound healing and tissue regeneration by their immunomodulatory property. Further studies are needed to
provide detailed information about active components of Manuka honey and their potential efficacy in different