Title:Review on Synthetic Chemistry and Antibacterial Importance of Thiazole Derivatives
VOLUME: 15 ISSUE: 3
Author(s):Ankita Kashyap, Nayana Adhikari, Arpita Das, Anshul Shakya, Surajit Kumar Ghosh, Udaya Pratap Singh and Hans Raj Bhat*
Affiliation:Department of Pharmaceutical Sciences, School of Science and Engineering, Dibrugarh University, Dibrugarh - 786 004, Assam, Department of Pharmaceutical Sciences, School of Science and Engineering, Dibrugarh University, Dibrugarh - 786 004, Assam, Department of Pharmaceutical Sciences, School of Science and Engineering, Dibrugarh University, Dibrugarh - 786 004, Assam, Department of Pharmaceutical Sciences, School of Science and Engineering, Dibrugarh University, Dibrugarh - 786 004, Assam, Department of Pharmaceutical Sciences, School of Science and Engineering, Dibrugarh University, Dibrugarh - 786 004, Assam, Drug Design & Discovery Laboratory, Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Science, Allahabad 211007, Department of Pharmaceutical Sciences, School of Science and Engineering, Dibrugarh University, Dibrugarh - 786 004, Assam
Keywords:Thiazole, chemistry, synthesis, antibacterial activity, DNA gyrase, derivatives.
Abstract:Background: Thiazole is one of the leading heterocyclic five-member
ring compounds that contain nitrogen and sulphur atom. Many natural and/or synthetic
compounds contain thiazole as an essential moiety and possess diverse therapeutic
activities. The thiazole ring was modified at different positions to generate
new molecules with potent antibacterial activities. Thus, the present review
enumerates the antibacterial importance of thiazole and its derivatives.
Method: The mining of literature has been performed using different database which
includes only peer-reviewed journals. The quality of retrieved papers was appraised
using standard tools. Moreover, the significant papers were described in detail to focus
on thiazole derivatives showing considerable antibacterial activity.
Result: The present review describes the chemistry, SAR (Structure Activity Relationship)
studies and antibacterial importance of thiazole with different synthetic procedures.
Conclusion: This particular study certainly benefits the researchers interested in exploiting
the antibacterial activity of thiazoles in search of novel agents.
