Review on Synthetic Chemistry and Antibacterial Importance of Thiazole Derivatives

Author(s): Ankita Kashyap, Nayana Adhikari, Arpita Das, Anshul Shakya, Surajit Kumar Ghosh, Udaya Pratap Singh, Hans Raj Bhat*

Journal Name: Current Drug Discovery Technologies

Volume 15 , Issue 3 , 2018

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Background: Thiazole is one of the leading heterocyclic five-member ring compounds that contain nitrogen and sulphur atom. Many natural and/or synthetic compounds contain thiazole as an essential moiety and possess diverse therapeutic activities. The thiazole ring was modified at different positions to generate new molecules with potent antibacterial activities. Thus, the present review enumerates the antibacterial importance of thiazole and its derivatives.

Method: The mining of literature has been performed using different database which includes only peer-reviewed journals. The quality of retrieved papers was appraised using standard tools. Moreover, the significant papers were described in detail to focus on thiazole derivatives showing considerable antibacterial activity.

Result: The present review describes the chemistry, SAR (Structure Activity Relationship) studies and antibacterial importance of thiazole with different synthetic procedures.

Conclusion: This particular study certainly benefits the researchers interested in exploiting the antibacterial activity of thiazoles in search of novel agents.

Keywords: Thiazole, chemistry, synthesis, antibacterial activity, DNA gyrase, derivatives.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2018
Published on: 02 July, 2018
Page: [214 - 228]
Pages: 15
DOI: 10.2174/1570163814666170911144036
Price: $65

Article Metrics

PDF: 37
PRC: 1