Background: Hypertension is a common health problem concerning a large proportion
of population and a leading global risk factor for the burden of cardiovascular disease (CVD).
The purpose of this study was to assess the efficacy of the erythrocyte zeta potential as a potential
additional indicator for cardiovascular disorder risk so that patients with this can be more rapidly
identified and treated.
Methods: In the present study, blood samples were collected in 5% dextrose solution from patients
suffering from hypertension and healthy volunteers (Not taken any medication). The mobility of
individual RBCs was tracked by equipped Zeta meter-ZM4DAQ software using microscopicallyacquired
video images, data were recorded 10 times for each sample and average zeta-potential in
mv was recorded.
Results: We found that mean erythrocytic ZP of control group was found to be 23.41 mv (± 1.87)
whereas, erythrocytic ZP for Hypertensive patients was found to be 16.05 (±1.72) mV and
Hypertensive patients with Diabetes is much lower from 6.96 mV to 22.76 (+3.88) mV along with
structural deformities and increased osmotic fragility of erythrocytes.
Conclusion: The data suggest that there are morphological changes in erythrocyte structure,
increased osmotic fragility along with significantly lower ZP value as compared to that of healthy
volunteers which may be the major cause for progression to the development of cardiovascular