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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Review Article

An Overview on Chemistry and Biological Importance of Pyrrolidinone

Author(s): Zahra Hosseinzadeh, Ali Ramazani*, Kamaleddin Hosseinzadeh, Nima Razzaghi-Asl and Farideh Gouranlou

Volume 15, Issue 2, 2018

Page: [166 - 178] Pages: 13

DOI: 10.2174/1570179414666170908165445

Price: $65

Abstract

Background: Pyrrolidinone is a five membered heterocyclic ring that is a versatile lead compound for designing powerful bioactive agents. Pyrrolidinone nucleus is one of the most important heterocyclic compound indicating notable pharmaceutical effects. Many procedures for the preparation of pyrrolidinone and also their various reactions offer great scope in the field of medicinal chemistry. This fascinating group of compounds has diverse pharmacological activities such as antibacterial, antifungal, anticancer and anticonvulsant.

Objective: The review article proposes to classify comprehensive information on chemistry and pharmaceutical effects of pyrrolidinone in order to open new viewpoint for future studies.

Conclusion: It is clear from the review of the topic that a wide spectrum of pyrrolidinone analogues have been synthesized and the majority of these derivatives have indicated different significant biological activities. Thus, these analogues can be used for future progression of novel drugs against many more poor agents.

Keywords: Pyrrolidinone, heterocyclic, biological activities, antimicrobial, anticancer, industrial applications.

Graphical Abstract

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