Background: Pharmaceutical industry is one of the most popular sectors known for spreading
of pollution. Here the association with various bases belonging to either organic or inorganic for
the enhancement of different transformation is a routine practice for manufacturing of active pharmaceutical
ingredients and their intermediates. This results in the destruction of environment directly or
indirectly because such bases are non-recoverable and non-recyclable.
Methods: Present investigation has focused on the advantage of application of century old hydrotalcite
as a green catalyst, which is recoverable and recyclable, in various organic transformations useful for
the synthesis of some active pharmaceutical ingredients and their intermediates. Here the authors have
identified research gap and disclosed novel green synthetic procedures catalyzed by hydrotalcite. Hydrolysis,
oxidation, S-Alkylation, Knovengel condensation and peptide bonding transformations were
tested in this protocol resulting in efficient, cost effective, eco-benign and industrially advantageous
Conclusion: This methodology was assessed by Reaction Mass Efficiency, one of the green metrics,
proving it to be eco-friendly as well as describing its financial importance which comes under green
and sustainable practices.