Solvent-free Synthesis and Antimicrobial Properties of Some Novel Furanone and Spiropyrimidone Derivatives

Author(s): Galal A. Elsayed*, Naglaa F.H. Mahmoud, Sameh A. Rizk

Journal Name: Current Organic Synthesis

Volume 15 , Issue 3 , 2018

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Abstract:

Background: The regioselective synthesis of spiro-heterocyclic compounds is intriguing since those compounds have unique non-planar structures and great potential for binding to biomolecules because of their inherent rigid chiral structure. A novel class of furanone and spiro-heterocyclic derivatives were synthesized and evaluated for antifungal activities to establish structure-activity relationship (SAR).

Results: The synthesis was carried out through one-pot multicomponent reaction (MCR) of 4-aryl-4-oxo-2- butenoic acids, camphor, urea, and hydrogen peroxide in the presence of sodium ethoxide as a catalyst using a microwave irradiation method and / or a traditional thermal method. They are used as key starting materials to synthesize some heterocyclic compounds. Structures of all synthesized compounds were elucidated by elemental analyses and spectroscopic data.

Conclusion: A facile and efficient method for the preparation of a new furanone, chalcone and spiropyrimidone derivatives via the one-pot MCR with the microwave-assisted irradiation was established.

Keywords: 4-Aryl-4-oxo-but-2-enoic acid, furanone, spiropyrimidone, pyridazin-3-one, spiropyrazole, 1, 2-oxazinone.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2018
Page: [404 - 413]
Pages: 10
DOI: 10.2174/1570179414666170830124447
Price: $65

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