Applications of Ammonium Bifluoride in Organic Synthesis

Author(s): Jia-Sheng Li, Wei-Zhe Dong, Hui Lu, Fu-Min Zhang*.

Journal Name: Current Organic Chemistry

Volume 22 , Issue 6 , 2018

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Graphical Abstract:


Background: Ammonium bifluoride is a reagent widely used in organic synthesis; however, the systematic collection and classification have not been covered until now.

Methodology: In this review, we aim to systematically summarize the application of ammonium bifluoride in organic synthesis.

Conclusion: It can be used for deprotection of hydroxyl protected groups (esp. Silyl protection). It is also used for introducing F & N atoms into organic molecules; promoting cyclization reactions acting as a multifunctional reagent.

Keywords: Ammonium bifluoride, removal of hydroxyl protecting groups, fluoride source, nitrogen source, cyclization, multifunction reagent, organic synthesis.

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Article Details

Year: 2018
Page: [581 - 589]
Pages: 9
DOI: 10.2174/1385272821666170830114140
Price: $58

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