Fate of T Cells and their Secretory Proteins During the Progression of Leprosy

Author(s): Mohd Tarique, Chaman Saini, Huma Naz, Raza Ali Naqvi, Faez Iqbal Khan*, Alpana Sharma*

Journal Name: Current Protein & Peptide Science

Volume 19 , Issue 9 , 2018

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Graphical Abstract:


Leprosy is an infectious disease caused by non-cultivable bacteria Mycobacterium leprae. Ridley and Jopling classified the disease into five polar forms, Tuberculoid (TT) and Lepromatous (LL), in between two forms of the disease Borderline tuberculoid (BT), Borderline (BB) and Borderline lepromatous (BL) are laid. The tuberculoid type (BT/TT) leprosy patients show good recall of cellmediated immune (CMI) response and Th1 type of immune response, while lepromatous leprosy (LL) patients show defect in cell-mediated immunity to the causative agent and Th2 type of immune response. Due to distinct clinical and immunological spectra of the disease, leprosy attracted immunologists to consider an ideal model for the study of deregulations of various immune reactions. Recent studies show that Tregs, Th3 (TGF-β, IL-10), IL-35 producing Treg immune response associated with the immune suppressive environment, survival of bugs. IL-17 producing Th17 immune response associated with tuberculoid leprosy and play protective role. γδ T cells also increased from tuberculoid to lepromatous pole of leprosy. In this review, we will discuss the role of various subtypes of T-cell and their cytokines in the pathogenesis of leprosy.

Keywords: Leprosy, Th1 and Th2 cells, Treg cells, pathogenesis of leprosy, tuberculoid leprosy, cytokines.

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Article Details

Year: 2018
Published on: 17 July, 2018
Page: [889 - 899]
Pages: 11
DOI: 10.2174/1389203718666170829120729
Price: $65

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