Aim and Objective: [(9H-Fluoren-9-yl)methoxy]carbonyl (Fmoc)-protected 2-aminoethanesulfonyl
chlorides with various functionalized 1-substituents may be of use as building blocks for the Fmoc strategic
synthesis of sulfonopeptides.
Material and Method: Fmoc-protected 2-aminoethanesulfonyl chlorides with different functionalized 1-
substituents were synthesized via radical addition of N-Fmoc allylamine and xanthates with functionalized Ssubstituents,
and subsequent oxidative chlorination with N-chlorosuccimide/HCl.
Results: Fmoc-protected 2-aminoethanesulfonyl chlorides with different functionalized 1-substituents were
synthesized via radical addition and subsequent oxidative chlorination. The mechanism on the oxidative chlorination
Conclusion: The current method is an expeditious, convenient, and practical method for the synthesis of Fmocprotected
2-aminoethanesulfonyl chlorides with different functionalized 1-substituents in good to excellent