Background: In the 20th century, cancer metabolism has been studied from different aspects.
In the last decade, the interest in this issue has been renewed and many studies have been carried out on
tumor and endothelial metabolism. Although tumor metabolism is well recognized, there are some discrepancies
between what we knew and what has been studied lately about the metabolism of endothelial
cells. Moreover, cancer and endothelial cells are not alone in their microenvironment. Immune cells and
fibroblasts are also present and have a crucial role in tumor-associated inflammation, as well as in tumor
progression, metastasis and angiogenesis. Nevertheless, metabolism of these cells is poorly understood.
Conclusion: In the present mini-review, information about metabolic characteristics of these cells is
summarized and compared with our knowledge about cancer and endothelial cell metabolism. This
knowledge could contribute to open up innovative approaches to the treatment of cancer.